Ultrasmall Lanthanide Oxide Nanoparticles for Biomedical Imaging and Therapy

by Gang Ho Lee, Jeong-Tae Kim

Most books discuss general and broad topics regarding molecular imagings. However, Ultrasmall Lanthanide Oxide Nanoparticles for Biomedical Imaging and Therapy, will mainly focus on lanthanide oxide nanoparticles for molecular imaging and therapeutics. Multi-modal imaging capabilities will discussed, along withup-converting FI by using lanthanide oxide nanoparticles. The synthesis will cover polyol synthesis of lanthanide oxide nanoparticles, Surface coatings with biocompatible and hydrophilic ligands will be discussed andTEM images and dynamic light scattering (DLS) patterns will be provided. Various techniques which are generally used in analyzing the synthesized surface coated nanoparticles will be explored andthis section will also cover FT­,IR analysis, XRD analysis, SQUID analysis, cytotoxicity measurements andproton relaxivity measurements.In vivo MR images, CT images, fluorescence images will be provided andTherapeutic application of gadolinium oxide nanoparticles will be discussed. Finally, future perpectives will be discussed. That is, present status and future works needed for clinical applications of lanthanide oxide nanoparticles to molecular imagings will be discussed.

• Synthesis will be discussed in detail
• General characterizations of nanoparticles before in vivo applications will be discussed
• The book will cover all possible applications of lanthanide oxide nanoparticles to molecular imagings such as MRI, CT, FI as well as therapeutics

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