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Primarily based on the above components, the treadmill SD methodology was used to establish an animal model of acute SD (DB036, Beijing). The treadmill SD model chosen on this experiment was first established on the United States Naval College of Aeronautics (WEBB, 1957). This method has been repeatedly improved, and scientists have step by step recognized that the experimental outcomes are relatively reliable and that this methodology decreases the amount of stress imposed on the tested animals (Xu et al., 2010). This technique causes much much less injury to animals than a standard water atmosphere or electrical stimulation. Using a mouse mannequin of SD, we found that modafinil improved studying and reminiscence, decreased proinflammatory issue (IL-1β, TNF-α, and IL-6) manufacturing, and increased the expression of anti-inflammatory elements (IL-10). As well as, modafinil induced an upregulation of brain-derived neurotrophic factor (BDNF) and synaptic activity. The membrane was incubated overnight with NLRP1 (1:1,000; ab98181; Abcam), NLRP3 (1:250; PA5-20838; Thermo Fisher Scientific), NLRC4 (1:1,000; 06-1125; MilliporeSigma), GSDMD (1:1,000; ab209845; Abcam), ASC (1:1,000; sc-22514-R; Santa Cruz Biotechnology, Dallas, TX, United States), cleaved caspase-1 (1:1,000; 67314; CST), IL-1β (1:1,000; 12242; CST), IL-18 (1:1,000; ab71495; Abcam), brain-derived neurotrophic factor (BDNF) (11,000; OSB00018G; Thermo Fisher Scientific), β-actin (1:5,000; 4971; CST), and GAPDH (1:5,000; 2118; CST) main antibodies at 4°C. After being washed with TBST, the membrane was incubated with the respective secondary antibodies.